Methods And Compositions Relating To The Regulation Of Muc1 By Hsf1 And Stat3

  • Published: Aug 14, 2008
  • Earliest Priority: Feb 02 2007
  • Family: 4
  • Cited Works: 0
  • Cited by: 0
  • Cites: 0
  • Sequences: 16
  • Additional Info: Full text Sequence
Abstract

This invention relates to regulation of cell signaling, cell growth, and more particularly to the regulation of cancer or inflammatory cell growth and/or activation. The invention provides methods of inhibiting interactions between MUC1 and a heat shock factor, method of inhibiting interactions between transcription factors and the MUC1 promoter, and methods of inhibiting MUC1 expression. The invention also provides screening methods for identifying compounds that inhibit the aforementioned interactions. Pharmaceutical compositions containing the identified compounds can be useful in treating cancers and inflammatory conditions.


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