Method For The Screening Of Molecules Useful In The Treatment And/or Prevention Of Alzheimer's Disease


The invention proposes blocking the channel of the γ-secretase enzymatic complex attributed to the formation of the Αβ42 peptide located in the structure of presenilin, preferably using molecules exhibiting specificity in relation to peptide determinants bordering the entry region to the channel from the extracellular space. Thus, the invention relates to the use of the presenilin channel ϒ42 as a pharmacological target for screening molecules that are suitable for improving cognitive performance and/or promoting cognitive development, preferably for the treatment and/or prevention of Alzheimer's disease.

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Document History
  • Publication: Mar 5, 2015
  • Application: Aug 26, 2014
    WO ES 2014070671 W
  • Priority: Aug 26, 2013
    ES ES 201331274 A

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