Graphical Models For The Analysis Of Genome-wide Associations

Abstract

Systems and methods are provided for the identification of genotype-phenotype associations in genome-wide association (GWA) studies. In an illustrative implementation, a data correlation environment comprises a population structure engine and at least one instruction set to instruct the population structure engine to process pedigree or population genetic data to generate a population structure sub-model according to a selected graphical model-based data correlation paradigm. Illustratively, the parameter of the resulting generalized linear mixed model can be learned using a variational approximation.


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Document History
  • Publication: Dec 31, 2009
  • Application: Jun 27, 2008
    US US 16377408 A
  • Priority: Jun 27, 2008
    US US 16377408 A

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