{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"057-704-817-144-396","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"057-704-817-144-396","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8838,"type":"PATENT","title":"Univ of Illinois Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":10245,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8209,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately = \"Univ Illinois\", \"Illinois Univ\", \"University of Illinois\", \"Illinois University\", \"University Illinois NOT Northern NOT southern NOT State\".
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Search Applicants and Owners separately: uni* illinois chicago
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Search Applicants and Owners separately = \"Univ Illinois\", \"Illinois Univ\", \"University of Illinois\", \"Illinois University\", \"University Illinois NOT Northern NOT southern NOT State\".
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Total patents: 9630
Search Applicants and Owners separately: uni* illinois chicago
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providing a composition comprising a candidate TLR2 antagonist;\n
contacting a TLR2 polypeptide comprising a TLR2 extracellular domain with a serum amyloid A (SAA) polypeptide in the presence of the composition; and\n
determining binding of the TLR2 polypeptide to the SAA polypeptide, wherein a disruption in binding of TLR2 to SAA compared to TLR2 binding to SAA in the absence of the composition indicates the composition is a TLR2 antagonist."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the candidate TLR2 antagonist is selected from the group consisting of: a small molecule, a macromolecule, a peptide, and a nonpeptide, wherein the small molecule, macromolecule, peptide, and nonpeptide can be naturally occurring or synthetic."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the composition further comprises a pharmaceutically acceptable carrier."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the TLR2 polypeptide is expressed on the surface of a cell."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 4, wherein the TLR2 polypeptide is expressed from a cDNA encoding full-length TLR2 expressed in the cell."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, wherein the cell further comprises a nucleic acid encoding a plurality of NF-κB binding sites operably linked to at least one expression control sequence and a reporter gene."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 6, wherein the reporter gene is luciferase."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 6, wherein determining the binding of the recombinant TLR2 polypeptide to the SAA polypeptide is by detecting expression of the reporter gene."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, wherein determining the binding of the recombinant TLR2 polypeptide to the SAA polypeptide is by detecting the expression of a SAA-inducible protein produced by the cell."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 9, wherein a SAA-inducible protein produced by the cell is a proinflammatory cytokine in the cell."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 10, wherein the cytokine is G-CSF."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the recombinant polypeptide comprising a TLR2 extracellular domain is fused to an antibody Fc fragment."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, wherein determining the binding of the recombinant TLR2 polypeptide to the SAA polypeptide is by ELISA assay."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 2, wherein the candidate TLR2 antagonist is an antibody."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the SAA polypeptide is a recombinant SAA polypeptide."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 15, wherein the recombinant SAA polypeptide is fusion protein."],"number":16,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}