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La présente invention a pour objet un polypeptide représenté par la formule :N-L-C, dans laquelle : N représente la séquence des acides aminés 25-81 de la gp41, C représente la séquence des acides aminés 112-157 de la gp41, et L représente une séquence de liaison flexible comprenant de 2 à 30 acides aminés, ainsi que son utilisation pour l'immunisation contre l'infection liée au VIH.
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