Tm-enhanced Blocking Oligonucleotides And Baits For Improved Target Enrichment And Reduced Off-target Selection

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Abstract

The invention is directed to modified oligonucleotide compositions and methods for selectively reducing unwanted nucleic acid contaminants and enriching for desired nucleic acid targets from complex genomic nucleic acid mixtures for sequencing applications. The modified oligonucleotide compositions include one or more modified groups that increase the Tm of the resultant oligonucleotide composition.


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