Methods Of Making Chemokine Alpha 3 Antibodies

Abstract

Human chemokine Alpha-3 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, sepsis, wound healing and psoriasis and to stimulate stem cell mobilization. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, ARDS and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.


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Document History
  • Publication: Sep 2, 2008
  • Application: Sep 8, 2004
    US US 93530604 A
  • Priority: Sep 8, 2004
    US US 93530604 A
  • Priority: May 10, 2002
    US US 14204602 A
  • Priority: May 10, 2002
    US US 14193802 A
  • Priority: Mar 18, 1997
    US US 81677297 A
  • Priority: Mar 18, 1996
    US US 1361596 P

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