Fused Pyrimidines As Inhibitors Of P97 Complex

  • Published: Aug 23, 2017
  • Earliest Priority: Jul 20 2012
  • Family: 35
  • Cited Works: 45
  • Cited by: 0
  • Cites: 7
  • Additional Info: Cited Works
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Abstract

Fused pyrimidine compounds having a saturated, unsaturated or aromatic A ring fused to a pyrimidine ring and having a complex substituents at the 2 position and a substituted amine at the 4 position of the pyrimidine ring as well as optional aliphatic, functional and/or aromatic components substituted at other positions of the pyrimidine ring and A ring are disclosed. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with p97 bioactivity such as cancer.


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