Inhibitors Of Human Phosphatidylinositol 3-kinase Delta

Abstract

Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kdelta) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kdelta plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kdelta, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kdelta activity, including compounds that selectively inhibit PI3Kdelta activity. Methods of using PI3Kdelta inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kdelta inhibitory compounds to inhibit PI3Kdelta-mediated processes in vitro and in vivo.


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Document History
  • Publication: Feb 11, 2003
  • Application: Apr 24, 2001
    US US 84134101 A
  • Priority: Apr 24, 2001
    US US 84134101 A
  • Priority: Oct 5, 2000
    US US 23805700 P
  • Priority: Apr 25, 2000
    US US 19965500 P

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