Fluorescent Protein Biosensors To Probe The Conformational Activation Of Cdk/cyclin Kinases

Abstract

The present invention relates to compounds comprising a polypeptide comprising an amino acid sequence derived from the sequence of a cyclin-dependent kinase (CDK) and at least one fluorophore coupled to an amino acid of said polypeptide. The invention also relates to said compounds associated with a technology enabling their intracellular delivery. The present invention also relates to the use of such compounds, or of compositions comprising said compounds, for determining if a product is capable of modulating the conformation of a CDK. More particularly, a compound according to the invention is usable for high-content high-throughput screening.


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Document History
  • Publication: May 22, 2014
  • Application: Nov 13, 2013
    WO EP 2013073747 W
  • Priority: Nov 13, 2012
    EP EP 12306401 A

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