1,2,4-thiazolidin-3-one Derivatives And Their Use In The Treatment Of Cancer

Abstract

According to the invention there is provided a compound of formula (I) wherein: A represents C(═N—W-D) or S; B represents S or C(—NH—W-D); when: A represents C(═N—W-D) and B represents S then the bond between B and the NH atom is a single bond; or A represents S and B represents C(—NH—W-D) then the bond between B and the NH atom is a double bond; X represents -Q-[CRxRy]n—; W represents —[CRxRy]m— or —C(O)—[CRxRy]p—; Q represents a bond, —N(Ra)—; —S—, or —O—; A1 to A5 respectively represent C(R1), C(R2), C(R3), C(R4) and C(R5), or, alternatively, up to two of A1 to A5 may independently represent N; D represents phenyl, pyridyl or pyrimidinyl optionally substituted by one or more R6 groups, which compounds are useful in the treatment of cancer.


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Document History
  • Publication: Jun 13, 2017
  • Application: Oct 14, 2015
    US US 201514883190 A
  • Priority: Oct 14, 2015
    US US 201514883190 A
  • Priority: Apr 4, 2012
    US US 201213381426 A
  • Priority: Jul 8, 2010
    GB GB 2010001315 W
  • Priority: Jul 8, 2009
    US US 21373509 P

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