Jasmonate Based Assays For Identifying Compounds That Selectively Inhibit Mitochondrial Bound Hexokinases

Abstract

The present invention provides compositions comprising compounds that selectively bind to hexokinases thereby promoting dissociation of these enzymes from mitochondria, and methods of use of such compounds and compositions to induce cell death in diseases and disorders characterized by the high levels of mitochondrial bound hexokinase. The present invention further discloses methods and assays for detecting and identifying molecules having these activities.


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Document History
  • Publication: Jan 8, 2013
  • Application: Mar 16, 2008
    US US 53120408 A
  • Priority: Mar 16, 2008
    US US 53120408 A
  • Priority: Mar 16, 2008
    IL IL 2008000366 W
  • Priority: Mar 15, 2007
    US US 91803207 P

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