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Reduction Of Polyalanine-induced Protein Aggregates And Toxicity By Ubiquilin

Abstract

A method for decreasing cell death in a cell exhibiting aggregation of polyalanine-containing proteins. The method includes introduction of an expression vector to a host cell comprising a nucleotide sequence encoding ubiquilin, followed by maintaining the transformed host cell under biological conditions sufficient for expression and accumulation of the ubiquilin in the host cell, wherein overexpression of ubiquilin reduces sensitivity of cell stress induced by expanded polyalanine proteins.


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Document History
  • Publication: Jul 3, 2008
  • Application: Dec 21, 2007
    WO US 2007/0088747 W
  • Priority: Dec 21, 2006
    US US 87645106 P

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