Aß-oligomer Measurement Method

Abstract

Disclosed is a method for measuring an Aß-oligomer by ELISA method, particularly a method for selectively measuring an Aß-oligomer having a relatively high molecular weight. The method for measuring an Aß-oligomer comprises the following steps (a) and (b): (a) contacting a monoclonal antibody (a first antibody) which can recognize a partial peptide comprising the amino acid sequence depicted in SEQ ID NO:1 and is bound to an insoluble carrier with a sample which is suspected to contain the Aß-oligomer, thereby binding the Aß-oligomer to the first antibody; and (b) reacting the Aß-oligomer bound to the first antibody in step (a) with a labeled monoclonal antibody (a second antibody) which can recognize a partial peptide comprising the amino acid sequence depicted in SEQ ID NO:1.


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Document History
  • Publication: Nov 12, 2009
  • Application: May 7, 2009
    WO JP 2009002004 W
  • Priority: May 8, 2008
    JP 2008121844 A

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