{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"040-435-125-967-48X","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"040-435-125-967-48X"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10826,"type":"PATENT","title":"KU Leuven - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":7336,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8278,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: univ* AND Leuven;
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3165
Search Applicants and Owners separately: univ* AND Leuven;
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3165
(a) contacting the sample with a first antibody that has high affinity for human MDA-modified LDL and human OxLDL wherein the first antibody is the monoclonal antibody mAb-4E6 produced by hybridoma Hyb4E6 deposited at the BCCM (Belgian Coordinated Collections of Microorganisms) under deposit accession number LMBP 1660 CB on Apr. 24, 1997; and
(b) thereafter visualizing and/or quantifying a binding reaction between the first antibody and the MDA-modified LDL and OxLDL present in the sample;
wherein the MDA-modified LDL and OxLDL for which the first antibody has high affinity contain at least 60 substituted lysine moieties per apo B-100 (apolipoprotein B-100) moiety."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 1 in which the MDA-modified LDL and OxLDL for which the first antibody has high affinity contain at least about 90 substituted lysine moieties per apo B-100 moiety."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 1 in which the MDA-modified LDL and OxLDL for which the first antibody has high affinity contain at least about 120 substituted lysine moieties per apo B-100 moiety."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 1 in which the MDA-modified LDL and OxLDL for which the first antibody has high affinity contain at least about 210 substituted lysine moieties per apo B-100 moiety."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 1 in which the MDA-modified LDL and OxLDL for which the first antibody has high affinity contain at least about 240 substituted lysine moieties per apo B-100 moiety."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 1 which is a competitive assay."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The competitive assay of claim 6 in which MDA-modified LDL and/or OxLDL are bound to a substrate, comprising contacting the sample and the first antibody with the substrate having bound to it MDA-modified LDL and OxLDL."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 1 which is a sandwich assay in which the first antibody is bound to a substrate, comprising contacting the sample with the substrate having bound to it the first antibody."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 8 in which a second antibody is used and the second antibody has high affinity for human MDA-modified LDL and human OxLDL."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 9 in which the second antibody has high affinity for human native LDL."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 1 which is an immunohistochemical assay in which the sample is a tissue sample and it is contacted with the first antibody."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 1 in which the affinity constant of the first antibody for MDA-modified LDL and for OxLDL is at least about 1×10 10 M −1 ."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 1 in which the first antibody has low affinity for human native LDL."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 3 in which the affinity constant of the first antibody for human native LDL is less than about 1×10 6 M −1 ."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 9 in which the affinity constant of the second antibody for MDA-modified LDL and for OxLDL is at least about 1×10 10 M −1 ."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 15 in which the affinity constant of the second antibody for human native LDL is at least about 1×10 9 M −1 ."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 16 in which the second antibody is the monoclonal antibody mAb-8A2 produced by hybridoma Hyb8A2 deposited at the BCCM under deposit accession number LMBP 1661 CB on Apr. 24, 1997."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 1 in which the sample is derived from the body fluids of a human being."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The assay of claim 1 in which at least one antibody is capable of detecting 0.02 mg/dl of human MDA-modified LDL and human OxLDL in undiluted human plasma."],"number":19,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}