Uses Of Dna-pk

Abstract

This invention provides methods for increasing the susceptibility of cells to DNA-damaging agents, and for treating tumors in a subject, comprising introducing antisense that prevent expression of DNA dependent protein kinase catalytic subunit Ku70 or Ku80, wherein the antisense is in an amount sufficient to increase the sensitivity of the cells and tumors to heat, chemical, or radiation-induced DNA damage.


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Document History
  • Publication: Apr 20, 2010
  • Application: Dec 28, 2000
    US US 75041000 A
  • Priority: Dec 28, 2000
    US US 75041000 A
  • Priority: Jun 30, 1999
    US US 9914702 W
  • Priority: Jun 30, 1998
    US US 9118198 P

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