Rnai Vitamin D Conjugates

Abstract

The invention provides non-hormonal vitamin D conjugated to therapeutic RNA compounds that result in the compounds having increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms. The vitamin D targeting groups are coupled to the therapeutic RNA compounds via the third carbon on the vitamin D backbone.


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Document History
  • Publication: Oct 17, 2017
  • Application: Oct 21, 2015
    US US 201514919671 A
  • Priority: Oct 21, 2015
    US US 201514919671 A
  • Priority: Oct 22, 2014
    US US 201462067400 P

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