Process For The Purification Of Carvedilol Or Its Salts Thereof

  • Published: Sep 4, 2008
  • Earliest Priority: Feb 26 2007
  • Family: 3
  • Cited Works: 1
  • Cited by: 0
  • Cites: 3
  • Additional Info: Full text
Abstract

The present invention provides processes for reducing bis impurities ((1,1 '-[2- (2-methoxyphenoxy)ethyl]iminobis-[3-(9H-carbazol-4-yloxy)]-propan-2-ol)), in particular Bis 1 and Bis 2, in carvedilol preparations. The process may comprise (a) combining carvedilol base with phosphoric acid in ethanol to obtain a reaction mixture; and (b) precipitating carvedilol phosphate from the reaction mixture, where the carvedilol phosphate comprises low levels of Bis 1 and Bis 2.


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Document History
  • Publication: Sep 4, 2008
  • Application: Jun 28, 2007
    WO US 2007/0015037 W
  • Priority: May 29, 2007
    US US 93220507 P
  • Priority: Apr 30, 2007
    US US 92709807 P
  • Priority: Feb 26, 2007
    US US 90369607 P

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