Azole Amides And Amines As Alpha V Integrin Inhibitors

  • Published: May 17, 2018
  • Earliest Priority: Nov 08 2016
  • Family: 5
  • Cited Works: 36
  • Cited by: 0
  • Cites: 9
  • Additional Info: Cited Works Full text

The present invention provides compounds of Formula (I): (Formula (I)), or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are inhibitors to αv-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αv-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.


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