Artificial Cell Constructs For Cellular Manipulation

Abstract

The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive agents which can increase the risk of infection, autoimmunity, and cancer. Immunological tolerance is thought to be mediated by regulatory T lymphocytes (Treg cells) with immunosuppressive capabilities. A therapeutically relevant platform comprising artificial constructs are contemplated comprising numerous soluble and surface bound Treg cell stimulating factors that may induce tolerance following allograft transplantation. Such artificial constructs, being the size of a cell, have surface bound monoclonal antibodies specific to regulatory T-cell surface moieties and encapsulated soluble regulatory T-cell modulating factors.


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Document History
  • Publication: Sep 12, 2017
  • Application: Jul 16, 2014
    US US 201414333000 A
  • Priority: Jul 16, 2014
    US US 201414333000 A
  • Priority: Feb 23, 2012
    US US 201213383122 A
  • Priority: Jul 9, 2010
    US US 2010/0041463 W
  • Priority: Jul 10, 2009
    US US 22457109 P

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