Method For Screening Compounds For The Treatment Or Prevention Of Colon Cancer

Abstract

The invention is in the field of molecular medicine, more in particular in the field of identifying new compounds for the treatment or prevention of colorectal cancer. The invention provides a method for the screening and/or identification of compounds that are capable of preventing or ameliorating the adverse effects of reactive oxygen species on eukaryotic cells. More in particular, the invention provides a method for the identification of an active therapeutic compound for preventing or ameliorating the adverse effects of reactive oxygen species on eukaryotic cells comprising the steps of:providing an assay wherein the expression of the WNT pathway in Caco cells can be determined under the influence of a reactive oxygen species, providing a candidate therapeutic compound, determining the ability of said therapeutic compound to normalize the expression of said WNT pathway in the presence or absence of said oxidant.


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Document History
  • Publication: Dec 16, 2010
  • Application: Jun 11, 2010
    WO EP 2010058225 W
  • Priority: Jun 11, 2009
    EP EP 09162498 A

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