Macromolecular Conjugates Of Cystic Fibrosis Transmembrane Conductance Regulator Protein Inhibitors And Uses Thereof

  • Published: Jul 3, 2008
  • Earliest Priority: Dec 22 2006
  • Family: 7
  • Cited Works: 0
  • Cited by: 3
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  • Additional Info: Full text Published

Provided herein are bioactive agents comprising a compound that inhibits the ion transport activity of a cystic fibrosis transmembrane conductance regulator (CFTR) and that is linked to a macromolecule that interacts with a cell that expresses CFTR. The bioactive agents described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, secretory diarrhea.


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