The invention relates to an isolated polynucleotide sequence comprising a nucleic acid sequence encoding the amino acid sequence of KshA protein or of KshB protein, encoded by nucleotides 499-1695 of SEQ ID NO:1 or by nucleotides 387-1427 of SEQ ID NO:2, respectively, and functional homologues thereof. The polynucleotides of the invention can be used to construct genetically modified microorganisms blocked in 3-ketosteroid 9alpha-hydroxylase activity, which are useful in the microbial degradation of steroids to accumulate certain steroid products.

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Document History
  • Publication: Apr 7, 2009
  • Application: Jan 18, 2007
    US US 65474807 A
  • Priority: Jan 18, 2007
    US US 65474807 A
  • Priority: Aug 5, 2004
    US US 50403404 A
  • Priority: Feb 19, 2003
    EP EP 0350025 W
  • Priority: Feb 21, 2002
    EP EP 02075723 A

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