Polyomavirus Diagnostic Reagents

Abstract

The present invention relates to HLA-A*02-restricted cellular epitopes within the VP1 polypeptide of human polyomaviruses, which are useful as diagnostic reagents for virus infection. Preferred peptides correspond to amino acids residues 107-116, 108-116 and 44-52 of BKV VP1, and are processed in vivo in natural infection with BKV. Effector T cell populations stimulated by the peptides represent functional CTLs as assessed by cytotoxicity and cytokine production, and are reactive against cells presenting both the BKV peptides above and the JC virus homolog sequences.


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Document History
  • Publication: Feb 16, 2010
  • Application: Nov 19, 2008
    US US 27380808 A
  • Priority: Nov 19, 2008
    US US 27380808 A
  • Priority: Jul 24, 2006
    US US 49154206 A
  • Priority: Jul 22, 2005
    US US 70148405 P

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