39-desmethoxy Derivatives Of Rapamycin


The present invention relates to novel 39-desmethoxyrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxyrapamycin derivatives in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.

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Document History
  • Publication: Jan 19, 2010
  • Application: Mar 10, 2006
    US US 90825006 A
  • Priority: Mar 10, 2006
    GB GB 2006000853 W
  • Priority: Mar 11, 2005
    GB GB 0504994 A

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