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(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 17 July 2008 (17.07.2008) (51) International Patent Classification: GOlN 33/00 (2006.01) C12P 19/34 (2006.01) C07H 21/04 (2006.01) C12M 1/36 (2006.01) C12Q 1/68 (2006.01) (21) International Application Number: PCT/US2007/089096 (22) International Filing Date: 2 8 December 2007 (28.12.2007) (25) Filing Language: (26) Publication Language: (30) Priority Data: 60/883,236 60/892,863 60/896,869 60/91 1,173 60,938,419 60,980,483 PCT (10) International Publication Number W O 2008/085777 A3 (74) Agents: WU, Nan et al; Cooley Godward Kronish LLP, 1200 19th Street, NW, Suite 500, Washington, District Of Columbia 20036-2402 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). English English 3 January 4 March 2 3 March 11 April 16 May 17 October 2007 2007 2007 2007 2007 2007 (03 .0 1.2007) (04.03.2007) (23 .03 .2007) ( 11.04.2007) (16.05.2007) (17.10.2007) US US US US US US (71) Applicant (for all designated States except US): XGENETICS INC. [US/US]; 1360 Chelsea Drive, Los Altos, California 94024 (US). (72) Inventor; and (75) Inventor/Applicant (for US only): SINGHAL, Ajay [US/US]; 1360 Chelsea Dr., Los Altos, CA 94024 (US). Published: — with international search report — before the expiration of the time limit for amending the claims and to be republished in the event o receipt of f amendments (88) Date of publication of the international search report: 16 October 2008 (54) Title: A METHOD FOR EARLY DETECTION OF CANCER (57) Abstract: The method i s a device or apparatus of unique design, material or a combination thereof, which identifies, separates, does imaging and classifies cells and prognostic bio-markers associated with cancer of epithelial nature. The contrivance uses a chip made of glass, silicon, quartz, a combination of these materials, or a plastic material, fabricated b y nanotechnology. The method can b e used to diagnose, monitor the disease state, disease progression, drug efficacy and a patient's treatment response. INTERNATIONAL SEARCH REPORT A IPC International application No PCT/US07/89096 CLASSIFICATION O F SUBJECT MATTER GOlN 33/00( 2006 01) C07H 21/04( 2006 01),C12Q l/68( 2006 01),C12P 19/34( 2006 01),C12M l/36( 2006 01) USPC 436/94 According to International Patent Classification (IPC) or to both national classification and IPC FIELDS SEARCHED Minimum documentation searched (classification system followed by classification symbols) U S 436/94, 536/23 1, 24 3 , 435/6, 9 1 1, 287 2 Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched Electronic data base consulted during the international search (name o f data base and, where practicable, search terms used) EAST (DATABAASES USPAT, USPGP, EPO, JPO, DERWENT) DOCUMENTS CONSIDERED T O B E RELEVANT Category * Citation o f document, with indication, where appropriate, o f the relevant passages U S 473 1325 (PALVA et a l ) 15 march 1998 (15 0 3 1998), see column 8 U S 2005/0123976 A l (MITAS et a l ) 09 June 2005 (09 0 6 2005), see abstract, and paragraphs 0010, 001 2 , 0028, 0038, 0052, 0056, and 0139 Relevant to claim N o 1-6 1-6 Further documents are listed in the continuation o f Box C • "A" See patent family annex "T" Special categories o f cited documents document defining the general state o f the art which i s not considered to b e o f particular relevance later document published after the international filing date o r priority date and not i n conflict with the application but cited to understand the principle o r theory underlying the invention "X" "E' "L" earlier application o r patent published o n o r after the international filing date document o f particular relevance, the claimed invention cannot b e considered novel o r cannot b e considered to involve an inventive step when the document is taken alone document o f particular relevance, the claimed invention cannot be considered to involve an inventive step when the document i s combined with one o r more other such documents, such combination being obvious to a person skilled in the art document member o f the same patent family document which may throw doubts o n priority cla ιm(s) o r which is cited to establish the publication date o f another citation o r other special reason (as specified) document referring to an oral disclosure, use, exhibition o r other means document published prior to the international filing date but later than the priority date claimed 'Y" "O" P "&" Date o f the actual completion o f the international search Datrøfinai .of t h iational search report 04 July 2008 (04 07 2008) Name and mailing address o f the ISA/US Mail Stop PCT, Attn ISA/US Commissioner for Patents P O Box 1450 Alexand πa , Virginia 22313-1450 Authorized officer /Bradley L Sisson/ Telephone No (57 1) 272-0600 Facsimile No (571) 273-3201 Form PCT/ISA/2 10 (second sheet) (April 2007)