Novel Therapeutics Based On Tau/microtubule Dynamics

Abstract

The invention is based on the discovery of a novel neuroprotective peptide. In addition, the invention rests on the discovery that the NAP peptide enhances the association of tau and the brain-specific beta tubulin subunit. In addition, NAP modifies microtubule assembly and dynamics, in part, by affecting the tyrosination of microtubule proteins. The invention provides compositions and methods for treatment and prevention of neuronal disorders, including NAP-binding and tau-binding agents, tau peptide mimetics, NAP-like and NAP-like tau peptide mimetics.


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Document History
  • Publication: Jul 17, 2008
  • Application: Jan 10, 2008
    WO IL 2008000047 W
  • Priority: Sep 5, 2007
    US US 97011007 P
  • Priority: Jan 11, 2007
    US US 88450207 P

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