Truncated Tau Proteins

Full-text?

The full document isn't yet available to us from the patent office.

Abstract

Described are novel N- and C-terminally double truncated tau molecules, herein after designated type IIB tau molecules, characterized by the following features: - the molecules have at least the first 68 N-terminal amino acids and at least the last 40 C-terminal amino acids of the 4 repeat containing tau43 or the first 68 N-terminal amino acids and at least the last 20 C-terminal amino acids of the 3 repeat containing tau44 truncated, - the molecules are detectable in Alzheimer's diseased brain tissue, whereas the molecules are not detectable in normal healthy brain tissue, - the molecules have a pathological microtubule assembly promoting activity different from wild type tau in an in vitro microtubule assembly assay.


Claims

Information currently unavailable.

CPC Classifications
Download PDF
Document Preview
Document History
  • Publication: Nov 26, 2008
  • Application: Jul 9, 2003
    EP EP 08014706 A
  • Priority: Jul 9, 2003
    EP EP 03763763 A
  • Priority: Jul 12, 2002
    AT AT 10532002 A

Download Citation


Sign in to the Lens

Feedback