{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"028-659-596-888-778","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"028-659-596-888-778"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11797,"type":"PATENT","title":"Queen's University at Kingston Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":5666,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8427,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: queen* AND univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1261
Search Applicants and Owners separately: queen* AND univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1261
a sequence encoding an influenza type hemagglutinin (HA) polypeptide or antigenic fragment thereof, or an influenza neuraminidase (NA) polypeptide or antigenic fragment thereof, wherein the sequence has been codon-optimized for expression in a human cell."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid of claim 1, wherein the sequence encodes an influenza type A HA polypeptide selected from the following subtypes: H1, H2, H3, H4, H5, H6, H7, H8, H9, H10, H11, H12, H13, H14, and H15."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid of claim 1, wherein the sequence encodes an HA polypeptide of the H1 subtype or the H3 subtype, and wherein the sequence is at least 90% identical to SEQ ID NO:1 or SEQ ID NO:3, or a fragment thereof containing at least 30 contiguous nucleotides of SEQ ID NO:1 or SEQ ID NO:3."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid molecule of claim 1, wherein the sequence further encodes a leader peptide that is not naturally associated with the influenza HA polypeptide."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid molecule of claim 1, wherein the sequence encodes an extracellular portion of HA."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid molecule of claim 3, wherein the sequence differs from SEQ ID NO:7 or SEQ ID NO:8 by between 5 and 200 nucleotides."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid of claim 1, wherein the sequence encodes an NA polypeptide, wherein the NA polypeptide is of the N2 subtype, and wherein the sequence is at least 90% identical to SEQ ID NO:5."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid molecule of claim 7, wherein the sequence differs from SEQ ID NO:9 by between 5 and 150 nucleotides."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["An isolated nucleic acid molecule comprising a sequence encoding two or more copies of an extracellular portion of an influenza M2 polypeptide."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid molecule of claim 9, further comprising a sequence encoding an influenza HA or NA polypeptide as a fusion with the two or more copies of the extracellular portion of the M2 polypeptide."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["A nucleic acid expression vector comprising the nucleic acid molecule of claim 1."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["A composition comprising: \n
(a) the nucleic acid molecule of claim 1;\n
(b) a mammalian promoter operably linked to the nucleic acid molecule, wherein the promoter directs transcription of mRNA encoding the influenza polypeptide; and\n
(c) a mammalian polyadenylation signal operably linked to the nucleic acid molecule."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 12, wherein the mammalian promoter is a cytomegalovirus immediate-early promoter."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 12, wherein the polyadenylation signal is derived from a bovine growth hormone gene."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 12, further comprising a pharmaceutically acceptable carrier."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 12, further comprising particles to which the isolated nucleic acid is bound, wherein the particles are suitable for intradermal, intramuscular, or mucosal administration."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["A cell comprising the nucleic acid molecule of claim 1."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["An isolated polypeptide encoded by the nucleic acid molecule of claim 1."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The polypeptide of claim 18, wherein the polypeptide is produced in a mammalian cell."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["An isolated antibody or antigen binding fragment thereof that specifically binds to a polypeptide of claim 18."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["A nucleic acid composition comprising: \n
(a) a first sequence encoding a first type of influenza polypeptide of a first influenza subtype; and\n
(b) a second sequence encoding the first type of influenza polypeptide of a second influenza subtype."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid composition of claim 21, wherein the first and second sequences encode a hemagglutinin (HA) polypeptide or antigenic fragment thereof, an influenza neuraminidase (NA) polypeptide or antigenic fragment thereof, or an influenza membrane ion channel (M2) polypeptide or an antigenic fragment thereof."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid composition of claim 21, wherein both the first and second influenza subtypes are influenza A subtypes; wherein both the first and second influenza subtypes are influenza B subtypes; or wherein the first influenza subtype is an influenza A subtype and the second influenza subtype is an influenza B subtype."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid composition of claim 23, wherein both the first and second subtypes are influenza A subtypes."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid composition of claim 24, wherein the first subtype is influenza A H1N1 and the second subtype is influenza A H3N2."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid composition of claim 21, wherein one or both sequences have been codon-optimized for expression in a mammalian cell."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid composition of claim 26, wherein the composition comprises a sequence at least 90% identical to SEQ ID NO:1, SEQ ID NO:3, or SEQ ID NO:5."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid composition of claim 21, further comprising a third sequence encoding the first type of influenza polypeptide of a third influenza subtype."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid composition of claim 21, further comprising a third sequence encoding a second type of influenza polypeptide."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid composition of claim 21, further comprising an influenza polypeptide."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising the nucleic acid composition of claim 21."],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid composition of claim 12, further comprising an adjuvant."],"number":32,"annotation":false,"title":false,"claim":true},{"lines":["A nucleic acid composition comprising: \n
(a) a first sequence encoding a first influenza polypeptide of a first influenza subtype; and\n
(b) a second sequence encoding a second influenza polypeptide of the first influenza subtype or a second influenza subtype;\n
wherein the sequence of (a) and the sequence of (b) have been codon-optimized for expression in a mammalian cell."],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid composition of claim 33, wherein the first and second influenza polypeptides are selected from a hemagglutinin (HA) polypeptide or antigenic fragment thereof, an influenza neuraminidase (NA) polypeptide or antigenic fragment thereof, or an influenza membrane ion channel (M2) polypeptide."],"number":34,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid composition of claim 33, further comprising a sequence encoding a third influenza polypeptide."],"number":35,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid composition of claim 34, wherein the first polypeptide is an influenza HA polypeptide comprising a sequence at least 90% identical to SEQ ID NO:1, SEQ ID NO:3, or SEQ ID NO:5."],"number":36,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid composition of claim 33, further comprising an influenza polypeptide."],"number":37,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising a nucleic acid composition of claim 33."],"number":38,"annotation":false,"title":false,"claim":true},{"lines":["The nucleic acid compositions of claim 33, further comprising an adjuvant."],"number":39,"annotation":false,"title":false,"claim":true},{"lines":["A method for inducing an immune response to one or more influenza polypeptides in a subject, the method comprising: \n
administering to the subject the composition of claim 12, wherein the composition is administered in an amount sufficient for the sequence to express the one or more influenza polypeptides at a level sufficient to induce an immune response in the subject."],"number":40,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 40, further comprising administering to the subject a second composition comprising an influenza polypeptide."],"number":41,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 41, wherein the second composition comprises influenza virions."],"number":42,"annotation":false,"title":false,"claim":true},{"lines":["A method for producing an influenza polypeptide, the method comprising: \n
providing the nucleic acid molecule of claim 1; and\n
expressing the nucleic acid in a host cell under conditions in which the influenza polypeptide encoded by the nucleic acid molecule is produced."],"number":43,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}