Compositions And Methods For Immunization Against Bacteria Expressing A Carbapenemase


The present invention provides vaccine and pharmaceutical compositions for treating or preventing bacterial inventions. The vaccine compositions of the invention include a carbapenemase such as a serine carbapenemase, a metallo-β-lactamase or an immunogenic fragment thereof. The pharmaceutical compositions include an anti-carbapenemase antibody or fragment thereof. Also provided are methods for treating and preventing a bacterial infection using the vaccine and pharmaceutical compositions of the invention. The invention further provides antibody conjugates that include an antibody or fragment thereof conjugated to a siderophore or an analog thereof.

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Document History
  • Publication: Oct 27, 2015
  • Application: Jan 24, 2013
    US US 201313749499 A
  • Priority: Jan 24, 2013
    US US 201313749499 A
  • Priority: Jan 27, 2012
    US US 201261591793 P

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