Targeting Bcl11a Distal Regulatory Elements For Fetal Hemoglobin Reinduction

Abstract

Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.


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Document History
  • Publication: Oct 29, 2015
  • Application: Nov 27, 2013
    US US 201314647547 A
  • Priority: Nov 27, 2013
    US US 201314647547 A
  • Priority: Nov 27, 2013
    US US 2013/0072236 W
  • Priority: Oct 10, 2013
    US US 201361889174 P
  • Priority: Mar 11, 2013
    US US 201361776144 P
  • Priority: Nov 27, 2012
    US US 201261730323 P
  • Priority: Nov 27, 2012
    US US 201261730369 P

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