{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"027-696-558-393-519","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"027-696-558-393-519"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10827,"type":"PATENT","title":"University of Arizona - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":8025,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8279,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: Univ* AND Arizona;
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4153
Search Applicants and Owners separately: Univ* AND Arizona;
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4153
(a) administering a first stimulus to the central nervous system of said test animal;\n
(b) measuring a physical response of said test animal to a second stimulus at one or more predetermined times following said administration; and\n
(c) comparing said physical response of said test animal to said second stimulus to a physical response of a control animal to said second stimulus at said one or more predetermined times following administration of a control stimulus to said control animal,\n
wherein an increased physical response of said test animal to said second stimulus, compared to said physical response of said control animal to said second stimulus, indicates a model for migraine pain."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["A method of modeling migraine pain in a test animal, said method comprising the steps of: \n
(a) administering a first stimulus capable of inducing migraine pain to the central nervous system of said test animal;\n
(b) measuring a physical response of said test animal to a second stimulus at one or more predetermined times following said administration; and\n
(c) comparing said physical response of said test animal to said second stimulus to a physical response of a control animal to said second stimulus at said one or more predetermined times following administration of a control stimulus to said control animal, thereby modeling migraine pain."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 or 2, wherein said first stimulus comprises a chemical stimulus."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 3, wherein said chemical stimulus comprises an inflammatory composition."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4, wherein said inflammatory composition comprises one or more compounds selected from the group consisting of histamine, bradykinin, prostaglandin E2, and serotonin."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 5, wherein said inflammatory composition comprises histamine, bradykinin, prostaglandin E2, and serotonin."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4, wherein said inflammatory composition comprises one or more compounds selected from the group consisting of a histamine agonist, a bradykinin agonist, a prostaglandin E2 agonist, and a serotonin agonist."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 3, wherein said chemical stimulus comprises calcitonin gene-related peptide (CGRP) or a CGRP agonist."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 3, wherein said chemical stimulus comprises a nitric oxide donor."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, wherein said nitric oxide donor is triglyceral nitrate (TGN) or s-nitrosylglutathione (SNOG)."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 3, wherein said chemical stimulus comprises a cytokine or a cytokine agonist."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 3, wherein said chemical stimulus comprises synthetic interstitial fluid."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 or 2, wherein said control stimulus is administered to the central nervous system of said control animal."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 or 2, wherein said first stimulus comprises a mechanical stimulus."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 14, wherein said mechanical stimulus comprises indenting the dura of said test animal."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 or 2, wherein said first stimulus comprises a chemical stimulus and a mechanical stimulus."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 or 2, wherein said first stimulus is administered to the dura of said test animal."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 or 2, wherein, prior to step (a), a craniotomy is performed on said test animal."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 18, wherein, prior to step (a) and subsequent to said craniotomy, said test animal is fitted with an intracerebroventricular cannula."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 18, wherein, prior to step (a) and subsequent to said craniotomy, said test animal is fitted with an intracranial guide tube."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 20, wherein said guide tube is placed within 5 millimeters of the dura of said test animal."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 21, wherein said guide tube does not penetrate into or through said dura."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 or 2, wherein said second stimulus comprises a tactile stimulus."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 23, wherein said test animal exhibits an increase in tactile hyperesthesia in comparison to said control animal."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 23, wherein said tactile stimulus comprises probing said test animal or control animal with a calibrated von Frey filament."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 25, wherein said von Frey filament is applied to the plantar surface of the hindpaw of said test animal or control animal."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 26, wherein said physical response of said test animal or control animal comprises a sharp withdrawal of said hindpaw."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 26, wherein step (c) further comprises determining the 50% paw withdrawal thresholds for said test animal and said control animal."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 28, wherein said test animal exhibits a reduction in said 50% paw withdrawal threshold in comparison to said control animal."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 25, wherein said von Frey filament is applied to the face of said test animal or control animal."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 30, wherein said physical response of said test animal or control animal comprises a sharp withdrawal of the head of said test animal or control animal."],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 30, wherein said physical response of said test animal or control animal comprises an attempt to grasp or bite said filament."],"number":32,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 30, wherein step (c) further comprises determining the 50% facial response thresholds for said test animal and said control animal."],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein said test animal exhibits a reduction in said 50% facial response threshold in comparison to said control animal."],"number":34,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 or 2, wherein said test animal is a mammal."],"number":35,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 35, wherein said test animal is a rat."],"number":36,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 35, wherein said test animal is a primate."],"number":37,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 or 2, wherein said test animal and control animal are of the same species."],"number":38,"annotation":false,"title":false,"claim":true},{"lines":["A method of identifying a compound that reduces migraine pain, said method comprising the steps of: \n
(a) administering a first stimulus to the central nervous system of a test animal;\n
(b) administering a candidate compound to said test animal;\n
(c) measuring a physical response of said test animal to a second stimulus at one or more predetermined times following said first stimulus; and\n
(d) comparing said physical response of said test animal to said second stimulus to a physical response of a control animal not receiving said candidate compound prior to said second stimulus,\n
wherein a decreased physical response of said test animal to said second stimulus, compared to said physical response of said control animal to said second stimulus is indicative of the therapeutic efficacy of said candidate compound for migraine pain."],"number":39,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein steps (a) and (b) are carried out in either order, or simultaneously."],"number":40,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein said candidate compound is administered systemically."],"number":41,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein said candidate compound is administered intracranially, topically, orally, intravenously, or subcutaneously."],"number":42,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein said candidate compound is administered to the central nervous system of said test animal."],"number":43,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 43, wherein said candidate compound is administered to the rostral ventromedial medulla of said test animal."],"number":44,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 43, wherein said candidate compound is administered to the dura of said test animal."],"number":45,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein said first stimulus comprises a chemical stimulus."],"number":46,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 46, wherein said chemical stimulus comprises an inflammatory composition."],"number":47,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 47, wherein said inflammatory composition comprises one or more compounds selected from the group consisting of histamine, bradykinin, prostaglandin E2, and serotonin."],"number":48,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 48, wherein said inflammatory composition comprises histamine, bradykinin, prostaglandin E2, and serotonin."],"number":49,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 47, wherein said inflammatory composition comprises one or more compounds selected from the group consisting of a histamine agonist, a bradykinin agonist, a prostaglandin E2 agonist, and a serotonin agonist."],"number":50,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 46, wherein said chemical stimulus comprises CGRP or a CGRP agonist."],"number":51,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 46, wherein said chemical stimulus comprises a nitric oxide donor."],"number":52,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 52, wherein said nitric oxide donor is triglyceral nitrate (TGN) or s-nitrosylglutathione (SNOG)."],"number":53,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 46, wherein said chemical stimulus comprises a cytokine or a cytokine agonist."],"number":54,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 46, wherein said chemical stimulus comprises synthetic interstitial fluid."],"number":55,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein said first stimulus comprises a mechanical stimulus."],"number":56,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 56, wherein said mechanical stimulus comprises indenting the dura of said test animal."],"number":57,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein said first stimulus comprises a chemical stimulus and a mechanical stimulus."],"number":58,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein said first stimulus is administered to the dura of said test animal."],"number":59,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein, prior to step (a), a craniotomy is performed on said test animal."],"number":60,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 60, wherein, prior to step (a) and subsequent to said craniotomy, said test animal is fitted with an intracerebroventricular cannula."],"number":61,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 60, wherein, prior to step (a) and subsequent to said craniotomy, said test animal is fitted with an intracranial guide tube."],"number":62,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 62, wherein said guide tube is placed within 5 millimeters of the dura of said test animal."],"number":63,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 63, wherein said guide tube does not penetrate into or through said dura."],"number":64,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 60, wherein, prior to step (a) and subsequent to said craniotomy, said test animal is fitted with a double cannula."],"number":65,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 65, wherein said double cannula is placed within 5 millimeters of the rostral ventromedial medulla of said test animal."],"number":66,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 66, wherein double cannula is placed in contact with the rostral ventromedial medulla of said test animal."],"number":67,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 66, wherein said candidate compound is administered through said double cannula."],"number":68,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein said second stimulus comprises a tactile stimulus."],"number":69,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 69, wherein said control animal exhibits an increase in tactile hyperesthesia in comparison to an animal that did not receive said first stimulus."],"number":70,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 70, wherein said test animal exhibits a decrease in tactile hyperesthesia in comparison to said control animal."],"number":71,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 70, wherein said tactile stimulus comprises probing said test animal or control animal with a calibrated von Frey filament."],"number":72,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 72, wherein said von Frey filament is applied to the plantar surface of the hindpaw of said test animal or control animal."],"number":73,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 73, wherein said physical response of said test animal or control animal comprises a sharp withdrawal of said hindpaw."],"number":74,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 73, wherein step (d) further comprises determining the 50% paw withdrawal thresholds for said test animal and said control animal."],"number":75,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 75, wherein said test animal exhibits an increase in said 50% paw withdrawal threshold in comparison to said control animal."],"number":76,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 72, wherein said von Frey filament is applied to the face of said test animal or control animal."],"number":77,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 77, wherein said physical response of said test animal or control animal comprises a sharp withdrawal of the head of said test animal or control animal."],"number":78,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 77, wherein said physical response of said test animal or control animal comprises an attempt to grasp or bite said filament."],"number":79,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 77, wherein step (d) further comprises determining the 50% facial response thresholds for said test animal and said control animal."],"number":80,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 80, wherein said test animal exhibits an increase in said 50% facial response threshold in comparison to said control animal."],"number":81,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein said test animal is a mammal."],"number":82,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 82, wherein said test animal is a rat."],"number":83,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 82, wherein said test animal is a primate."],"number":84,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein said test animal and control animal are of the same species."],"number":85,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}