Methods And Devices For Stimulating An Immune Response Using Nanosecond Pulsed Electric Fields


Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on size and type of a tumor to stimulate an immune response against the tumor and other tumors in a subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.

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Document History
  • Publication: May 23, 2017
  • Application: Jul 22, 2015
    US US 201514805828 A
  • Priority: Jul 22, 2015
    US US 201514805828 A
  • Priority: May 27, 2014
    US US 201414287957 A
  • Priority: Jun 3, 2013
    US US 201361830564 P

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