Alkynyl Pyrrolo[2,3-d]Pyrimidines And Related Analogs As Hsp90-inhibitors

Abstract

Alkynyl pyrrolo[2,3-d]pyrimidines and related analogs are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents used in the treatment and prevention of various HSP90 mediated disorders. Methods of synthesis and use of such compounds are also described and claimed.


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