Transgenic Cells And Animals For The Study Of The Polarization Of The Immune Response


The invention relates to a transgenic non-human animal cell expressing at least one transgene coding for at least one reporter protein, characterized in that the expression of said reporter protein is correlated to the expression of at least one protein which is naturally produced by said cell and which is specific for a type of polarization of the immune response and/or an effector function of the immune response. The invention also relates to a corresponding transgenic animal. According to the invention, the cell and the transgenic animal can be used in a method for characterizing the type of immune response, i.e. Th1 and Th 2, caused by an immunogene, a pathogen or chemical agent.


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