Modified Cyclic Nucleotide Gated Ion Channels

Abstract

The present invention provides modified cyclic nucleotide gated (CNG) channels. In particularly preferred embodiments, the modified CNG channels exhibit increased sensitivity and specificity for cAMP, as compared to wild-type CNG channels. In additional embodiments, regulation by Ca<SUP>2+</SUP>-calmodulin has been removed in the modified CNG channels. Convenient optical methods for detecting changes in cAMP, taking advantage of the Ca<SUP>2+</SUP> permeability of the channel are also provided by the present invention. In addition, electrophysiological methods are further provided.


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Document History
  • Publication: Mar 11, 2008
  • Application: Nov 16, 2006
    US US 60140806 A
  • Priority: Nov 16, 2006
    US US 60140806 A
  • Priority: Nov 15, 2002
    US US 29557302 A
  • Priority: Nov 16, 2001
    US US 33249401 P

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