Role Of Pld1 In Thrombus Formation And Integrin Alpha Iib Beta 3 Activation

Abstract

The present invention relates to an inhibitor of phospholipase D1(PLD1) or an inhibitor of a direct activator of PLD1 for use in treating or preventing a disorder related to venous or arterial thrombus formation. Alternatively the present invention relates to the use of such an inhibitor as a lead compound for developing a drug for treating or preventing a disorder related to venous or arterial thrombus formation. The present invention also relates to a method of treating and/or preventing a disorder related to venous or arterial thrombus formation comprising administering a pharmaceutically effective amount of an inhibitor of phospholipase D1(PLD1) or an inhibitor of a direct activator of PLD1 to a subject in need thereof. The present invention further relates to methods of identifying a compound suitable as a lead compound and/or as a medicament for the treatment and/or prevention of a disorder related to venous or arterial thrombus formation.


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Document History
  • Publication: Jan 13, 2011
  • Application: Jul 1, 2010
    WO EP 2010059405 W
  • Priority: Jul 10, 2009
    EP EP 09009063 A

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