Leukaemia Stem Cell Line, Its Method Of Production And Uses Thereof

Abstract

Bromodomain and extra terminal protein (BET) resistant leukemic cell lines and methods for producing such cell lines are described as are methods for using such cell lines in screening assays to identify therapeutic agents. The cell lines can be generated from haematopoietic stem and progenitor cells (HSPCs) that are clonally enriched by serially exposing c-kit positive cells to a BET inhibitor.


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Document History
  • Publication: Feb 20, 2018
  • Application: Mar 11, 2016
    US US 201615067991 A
  • Priority: Mar 11, 2016
    US US 201615067991 A

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