Compositions And Methods For Systemic Inhibition Of Cartilage Degradation

Abstract

Methods and compositions for inhibiting articular cartilage degradation. The compositions preferably include multiple chondroprotective agents, including at least one agent that promotes cartilage anabolic activity and at least one agent that inhibits cartilage catabolism. The compositions may also include one or more pain and inflammation inhibitory agents. The compositions may be administered systemically, such as to treat patients at risk of cartilage degradation at multiple joints, and suitably may be formulated in a carrier or delivery vehicle that is targeted to the joints. Alternatively the compositions may be injected or infused directly into the joint.


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Document History
  • Publication: Jun 27, 2006
  • Application: Jan 31, 2003
    US US 35664903 A
  • Priority: Jan 31, 2003
    US US 35664903 A
  • Priority: Feb 1, 2002
    US US 35355202 P
  • Priority: Jan 18, 2002
    US US 3154602 A
  • Priority: Apr 20, 2001
    US US 83963301 A
  • Priority: Jul 21, 2000
    US US 0019864 W
  • Priority: Nov 5, 1999
    US US 9926330 W
  • Priority: Oct 20, 1999
    US US 9924625 W
  • Priority: Jul 21, 1999
    US US 14490499 P
  • Priority: Nov 5, 1998
    US US 10725698 P
  • Priority: Oct 20, 1998
    US US 10502698 P

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