Notch-based Fusion Proteins And Uses Thereof

Abstract

This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide.


Claims
Download PDF
Document Preview
Document History
  • Publication: Feb 16, 2010
  • Application: Apr 26, 2005
    US US 11496205 A
  • Priority: Apr 26, 2005
    US US 11496205 A
  • Priority: Apr 29, 2004
    US US 56687704 P

Download Citation


Sign in to the Lens

Feedback