Novispirins: Antimicrobial Peptides

Abstract

Novispirin peptides are antimicrobial agents with potent activity against Gram-negative bacteria. The peptides are nonhemolytic, exhibit reduced in vitro cytotoxicity relative to other antimicrobial peptides, and were well-tolerated in vivo after intravenous injection. Novispirins also bind lipopolysaccharide (LPS), a property that may mitigate symptoms associated with Gram-negative bacterial infection. A pharmaceutical composition comprising novispirin as an active agent is administered to a patient suffering from or predisposed to a microbial infection, particularly Gram-negative bacterial infections.


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Document History
  • Publication: Jun 27, 2002
  • Application: Apr 19, 2001
    US US 84000901 A
  • Priority: Apr 19, 2001
    US US 84000901 A
  • Priority: Jun 28, 2000
    US US 60685800 A

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