{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"020-318-680-241-196","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"020-318-680-241-196","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11710,"type":"PATENT","title":"University of Barcelona - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":890,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8364,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: uni* barcelona
Select more for logical variants.
Add to collection.
Select all patents in the collection and expand by simple families.
Add to collection. Total patents: 902
Search Applicants and Owners separately: \"Institute of Photonic Sciences\";icfo;crg; iciq;Català d'Investigació Química; icn2;Català Nanociència Nanotecnologia; Física d'Altes Energies;IRB Barcelona. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 318
Search Applicants and Owners separately: uni* barcelona
Select more for logical variants.
Add to collection.
Select all patents in the collection and expand by simple families.
Add to collection. Total patents: 902
Search Applicants and Owners separately: \"Institute of Photonic Sciences\";icfo;crg; iciq;Català d'Investigació Química; icn2;Català Nanociència Nanotecnologia; Física d'Altes Energies;IRB Barcelona. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 318
R1; R2 and R3 are independently selected from the group consisting of C1-4alkoxy, C1-4alkylcarbonyloxy, benzyloxy, phenylcarbonyloxy, naphthylcarbonyloxy, quinolinylcarbonyloxy and isoquinolinylcarbonyloxy;
R4 is selected from the group consisting of halogen, nitrile, C1-4alkoxy, C1-4alkylthio, C1-4alkyl, phenyl, phenoxy, phenylthio and trifluoromethyl;
R5 is selected from the group consisting of hydrogen, fluor and methyl;
or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["Compound according to claim 1 wherein R1 and R3 are independently selected from the group consisting of C1-4alkoxy, C1-4alkylcarbonyloxy and benzyloxy"],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["Compound according to claim 2, wherein R1 and R3 are methoxy."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["Compound according to any of claims 1 to 3, wherein R2 is a benzyloxy."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["Compound according to any of claims 1 to 4, wherein R4 is selected from fluor, methoxy, methylthio and phenyl."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["Compound according to claim 5, wherein R4 is fluor."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["Compound according to any of claims 1 to 6, wherein R5 is hydrogen or fluor."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["Compound according to any of claims 1 to 4, wherein said compound is selected from:
● (S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxypyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
● (S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-fluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
● (S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-phenylpyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
● (S)-1-((2S)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4,4-difluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
● (S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-(methylthio)pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
● (S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methylpyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
● (S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-cyanopyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
● (S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-(trifluoromethyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
●(S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-(tert-butoxy) pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
● (S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-acetoxypyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
● (S)-1-((2S)-1-(4-acetoxy-3,5-dimethoxybenzoyl)-4,4-difluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
● (S)-1-((2S)-1-(4-benzoyloxy-3,5-dimethoxybenzoyl)-4,4-difluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
● (S)-1-((2S)-1-(3,4-dibenzyloxy-5-methoxybenzoyl)-4,4-difluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
● (S)-1-((2S)-1-(3,4-dibenzoyloxy-5-methoxybenzoyl)-4,4-difluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
● (S)-1-((2S)-1-(3-acetoxy-4,5-dimethoxybenzoyl)-4,4-difluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
● (S)-1-((2S)-1-(3-pivaloyloxy-4,5-dimethoxybenzoyl)-4,4-difluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrileor a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["A process for the preparation of a compound of formula (I) as defined in any of claims 1 to 8 or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof, which comprises
a) reacting a compound of formula (IX): in which R1, R2, R3, R4 and R5 are as defined above in formula (I), with a compound of formula (XI): to yield a compound of formula (XII);
b) hydrolising the compound of formula (XII) to yield the compound of formula (XIV) and
c) subjecting the compound of formula (XIV) to conditions capable of transforming a carboxamide group into a nitrile group to yield the compound of formula (I);wherein steps b) and c) may be performed separately or in a one pot reaction."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["A process for the preparation of a compound of formula (I) as defined in any of claims 1 to 8 or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof, which comprises reacting a compound of formula (IX): in which R1, R2, R3, R4 and R5 are as defined above in formula (I), with a compound of formula (IV)"],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition comprising at least one compound of formula (I) as defined in any of claims 1 to 8, or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof and a pharmaceutically acceptable carrier, adjuvant or vehicle."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["A compound of formula (I) as defined in any of claims 1 to 8 for use as a medicament."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["A compound of formula (I) as defined in any of claims 1 to 8 for use in the treatment and/or prophylaxis of a cognitive disorder."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["A compound for use as defined in claim 13 wherein the cognitive disorder is a cognitive disorder associated with a disease selected from the group consisting of schizophrenia, bipolar affective disorder, Alzheimer's disease and Parkinson's disease."],"number":14,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}