Long Interspersed Nuclear Elements (line-1) And Alu Hypomethylation As Biomarkers For Colorectal Cancer Metastasis


A method for determining a colorectal cancer metastasis in a human subject suffering from a primary colorectal cancer (CRC) is described herein. The method of the present invention comprises the steps of: i) identifying the human subject suffering from the primary CRC, ii) obtaining one or more biological samples from the human subject, iii) detecting a methylation level of Alu, LINE-1, or both in the one or more biological samples, and iv) increasing the level of the colorectal metastatic stage in the human subject when the methylation level of Alu, LINE-1 is lower compared to a corresponding control methylation level of Alu, LINE-1.

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Document History
  • Publication: Sep 20, 2012
  • Application: Feb 29, 2012
    US US 201213408947 A
  • Priority: Feb 29, 2012
    US US 201213408947 A
  • Priority: Mar 18, 2011
    US US 201161454119 P

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