Mva Vaccine For Delivery Of A Ul128 Complex And Preventing Cmv Infection

Abstract

In one embodiment, an expression system for expressing a UL128 complex is provided herein. The expression system may include a bacterial artificial chromosome (BAC) construct, wherein the BAC construct comprises a viral vector inserted with a set of DNA sequences that encode a UL128 complex. In another embodiment, a vaccine composition for preventing HCMV infection is provided. The vaccine composition may include a viral or bacterial vector capable of expressing a UL128 complex and a pharmaceutically acceptable carrier, adjuvant, additive or combination thereof or additional vector expressing a protein adjuvant. The viral vector may be an MVA and the UL128 complex includes five HCMV proteins or antigenic fragments thereof: UL128, UL130, UL131A, gL, and gH. In some embodiments, the viral vector is further inserted with one or more additional DNA sequences that encode one or more additional HCMVHCMV proteins or antigenic fragments thereof such as pp65, gB or both, or such as gM/gN or gO.


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Document History
  • Publication: Aug 13, 2019
  • Application: Mar 12, 2018
    US US 201815919110 A
  • Priority: Mar 12, 2018
    US US 201815919110 A
  • Priority: Jan 27, 2015
    US US 201514606973 A
  • Priority: Mar 15, 2013
    US US 2013/0032554 W
  • Priority: Jul 27, 2012
    US US 201261676846 P

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