Compositions And Methods For Inhibiting Adipogenesis By Inhibition Of Constitutive Coactivator Of Ppargamma


This invention relates generally to compositions and methods which utilization nuclear receptors for regulating adipogenesis in cells. Specifically, the invention is directed to compositions which regulate transcription factor PPARγ, and enhance or inhibit the transcription of genes responsible for directing cell differentiation towards a pathway of adipogenesis. More specifically, disclosed herein is a novel polypeptide coactivator of PPARγ, and fragments thereof, which possess coactivator or corepressor activity. Also related are nucleotide sequences which express these polypeptides. Also disclosed is an interfering RNA that may be used to inhibit adipogenesis.

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Document History
  • Publication: Jan 15, 2013
  • Application: Aug 30, 2010
    US US 87099110 A
  • Priority: Aug 30, 2010
    US US 87099110 A
  • Priority: Oct 11, 2007
    US US 87073607 A
  • Priority: Oct 12, 2006
    US US 85115606 P

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