US 2009/0061048 A1 - Delivery And Controlled Release Of Encapsulated Lipophilic Nutrients - The Lens

Delivery And Controlled Release Of Encapsulated Lipophilic Nutrients

Published: Mar 5, 2009
Earliest Priority: Aug 28 2007
Family: 22
Cited Works: 0
Cited by: 13
Cites: 100
Additional Info: Full text

Abstract

A complex coacervate delivery system is provided which encapsulates lipophilic nutrients such as, for example, fish oils high in omega-3 fatty acids. The complex coacervate delivery system protects the lipophilic nutrient from degradation, e.g., oxidation and hydrolysis, and also reduces or eliminates the unpleasant taste and odor of the lipophilic nutrient. The complex coacervate delivery system upon ingestion is operative to substantially release the lipophilic nutrient in the lower gastrointestinal tract in a pH-controlled manner. The complex coacervate delivery system may be included in a food or beverage product having a pH value within the range of about 1.5 to about 5.0.

Claims

A complex coacervate delivery system comprising an aqueous dispersion of complex coacervates;
wherein the complex coacervates comprise:
a shell comprising at least one food-grade cationic polymer and at least one food-grade anionic polymer; and

a core comprising at least one lipophilic nutrient;

wherein the complex coacervate delivery system upon ingestion is operative to substantially release the lipophilic nutrient in the lower gastrointestinal tract.
The complex coacervate delivery system of claim 1, which is stable at at least one pH value within the range of 1.5 to 5.0.
The complex coacervate delivery system of claim 1, which is stable at at least one pH value within the range of 2.8 to 4.0.
The complex coacervate delivery system of claim 1, wherein the complex coacervate delivery system is operative to substantially release the lipophilic nutrient in the lower gastrointestinal tract at a pH value within the range of pH 6.0 and above.
The complex coacervate delivery system of claim 4, wherein the complex coacervate delivery system is operative to substantially release the lipophilic nutrient in the lower gastrointestinal tract at any pH value within the range of pH 6.0 and above.
The complex coacervate delivery system of claim 4, wherein the complex coacervate delivery system is operative to substantially release the lipophilic nutrient in the lower gastrointestinal tract at one or more pH values within the range of pH 6.0 and above.
The complex coacervate delivery system of claim 1, wherein the lipophilic nutrient comprises at least one of fatty acids, fat soluble vitamins, vitamin A, vitamin D, vitamin E, vitamin K, tocotrienols, carotenoids, xanthophylls, lycopene, lutein, astaxanthin, zeazanthin, fat-soluble nutraceuticals, phytosterols, stanols and esters thereof, Coenzyme Q10, ubiquinol, hydrophobic amino acids and peptides, essential oils and extracts.
The complex coacervate delivery system of claim 7, wherein the fatty acid comprises at least one of conjugated linolenic acid (CLA), one or more omega-3 fatty acids, and one or more omega-6 fatty acids
The complex coacervate delivery system of claim 8, wherein the omega-3 fatty acid comprises at least one of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
The complex coacervate delivery system of claim 8, wherein the omega-3 fatty acid comprises 55-65% EPA and 45-35% DHA.
The complex coacervate delivery system of claim 1, wherein the core further comprises at least one weighting agent.
The complex coacervate delivery system of claim 11, wherein the weighting agent comprises at least one of ester gum, sucrose acetate isobutyrate, and brominated vegetable oil.
The complex coacervate delivery system of claim 1, wherein at least a majority of the complex coacervates have a particle size within the range of 0.1 μm to 5.0 μm.
The complex coacervate delivery system of claim 1, wherein at least a majority of the complex coacervates have a particle size within the range of 0.1 μm to 2.0 μm.
The complex coacervate delivery system of claim 1, wherein at least a majority of the complex coacervates have a particle size within the range of 0.3 μm to 0.5 μm.
The complex coacervate delivery system of claim 1, wherein the cationic polymer comprises at least one of dairy proteins, whey proteins, caseins and fractions thereof, gelatin, corn zein protein, bovine serum albumin, egg albumin, grain protein extracts, vegetable proteins, microbial proteins, legume proteins, proteins from tree nuts, proteins from ground nuts, and chitosan.
The complex coacervate delivery system of claim 1, wherein the anionic polymer comprises at least one of pectin, carrageenan, alginate, xanthan gum, modified celluloses, carboxymethylcellulose, gum acacia, gum ghatti, gum karaya, gum tragacanth, locust bean gum, guar gum, psyllium seed gum, quince seed gum, larch gum (arabinogalactans), stractan gum, agar, furcellaran, modified starches, gellan gum, and fucoidan.
The complex coacervate delivery system of claim 1, wherein the cationic polymer comprises gelatin and the anionic polymer comprises gum acacia.
The complex coacervate delivery system of claim 1, wherein the weight to weight ratio of cationic polymer to anionic polymer is from 10:1 to 1:10.
The complex coacervate delivery system of claim 1, wherein the weight to weight ratio of cationic polymer to anionic polymer is about 4:1.
The complex coacervate delivery system of claim 1, wherein the shell is substantially non-crosslinked.
The complex coacervate delivery system of claim 1, wherein the shell is substantially non-gelled.
The complex coacervate delivery system of claim 1, wherein the complex coacervates are substantially non-agglomerated.
A complex coacervate delivery system comprising an aqueous dispersion of complex coacervates;
wherein the complex coacervates comprise:
a shell comprising a food-grade cationic polymer and a food-grade anionic polymer; and

a core comprising at least one lipophilic nutrient;

wherein the complex coacervate delivery system is operative to substantially release the lipophilic nutrient in a pH-controlled manner.
A complex coacervate delivery system comprising an aqueous dispersion of substantially not agglomerated complex coacervates, wherein the complex coacervates comprise:
a substantially non-crosslinked, substantially non-gelled shell comprising gelatin and gum acacia in a weight to weight ratio of about 4:1; and

a core comprising an omega-3 fatty acid;

wherein the complex coacervates have a particle size of 0.1 μm to 0.5 μm;

wherein the complex coacervate delivery system has a pH value within the range of 2.8 to 4.0; and

wherein the complex coacervate delivery system upon ingestion is operative to substantially release the omega-3 fatty acid in the lower gastrointestinal tract at a pH value within the range of pH 6.0 and above.
An aqueous dispersion of complex coacervates, wherein the complex coacervates comprise:
a shell comprising at least one food-grade cationic polymer and at least one food-grade anionic polymer; and

a core comprising at least one lipophilic nutrient;

wherein the aqueous dispersion of complex coacervates is operative to substantially release the lipophilic nutrient in a pH-controlled manner.
A beverage product comprising a complex coacervate delivery system comprising an aqueous dispersion of complex coacervates, wherein the complex coacervates comprise:
a shell comprising at least one food-grade cationic polymer and at least one food-grade anionic polymer, and

a core comprising at least one lipophilic nutrient;

wherein the beverage product has a pH value within the range of 1.5 to 5.0; and

wherein upon ingestion of the beverage product, the complex coacervate delivery system is operative to substantially release the lipophilic nutrient in the lower gastrointestinal tract in a pH-controlled manner.
The beverage product of claim 27, wherein the beverage product comprises a ready-to-drink beverage.
The beverage product of claim 27, wherein the beverage product is selected from the group consisting of carbonated beverages, non-carbonated beverages, fountain beverages, liquid concentrates, fruit juices, fruit juice-flavored drinks, sports drinks, energy drinks, fortified/enhanced water drinks, soy drinks, vegetable drinks, grain-based drinks, malt beverages, fermented drinks, yogurt drinks, kefir, coffee beverages, tea beverages, dairy beverages, and mixtures thereof.
The beverage product of claim 27, wherein upon ingestion of the beverage product, the complex coacervate delivery system is operative to substantially release the lipophilic nutrient in the lower gastrointestinal tract at a pH value within the range of pH 6.0 and above.
A food product comprising a complex coacervate delivery system comprising an aqueous dispersion of complex coacervates, wherein the complex coacervates comprise:
a shell comprising at least one food-grade cationic polymer and at least one food-grade anionic polymer, and

a core comprising at least one lipophilic nutrient;

wherein the food product has a pH value within the range of 1.5 to 5.0; and

wherein upon ingestion of the food product, the complex coacervate delivery system is operative to substantially release the lipophilic nutrient in the lower gastrointestinal tract in a pH-controlled manner.
The food product of claim 31, wherein the food product is selected from the group consisting of fermented food products, yogurt, sour cream, cheese, salsa, ranch dip, fruit sauces, fruit jellies, fruit jams, and fruit preserves.
The food product of claim 31, wherein upon ingestion of the food product, the complex coacervate delivery system is operative to substantially release the lipophilic nutrient in the lower gastrointestinal tract at a pH value within the range of pH 6.0 and above.
A complex coacervate delivery system comprising an aqueous dispersion of complex coacervates;
wherein the complex coacervates comprise:
a shell comprising at least one cationic polymer and at least one anionic polymer; and

a core comprising at least one lipophilic nutrient;

wherein the complex coacervate delivery system upon ingestion is operative to substantially release the lipophilic nutrient in a pH-controlled manner.
The complex coacervate delivery system of claim 34, wherein the cationic polymer comprises at least one of Eudragit E, Eudragit E 100, and Eudragit E PO.
The complex coacervate delivery system of claim 34, wherein the anionic polymer comprises at least one of pectin, carrageenan, alginate, xanthan gum, modified celluloses, carboxymethylcellulose, gum acacia, gum ghatti, gum karaya, gum tragacanth, locust bean gum, guar gum, psyllium seed gum, quince seed gum, larch gum (arabinogalactans), stractan gum, agar, furcellaran, modified starches, gellan gum, and fucoidan.