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(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 1 5 March 2012 (15.03.2012) (10) International Publication Number PO PCT WO 2012/031603 A 3 CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (51) International Patent Classification: A61K 9/72 (2006.01) A61P 35/00 (2006.01) A61K 31/454 (2006.01) A61P 11/00 (2006.01) (21) International Application Number: PCT/DK201 1/050338 (22) International Filing Date: >September 201 1 (09.09.201 1) (84) Designated States (unless otherwise indicated, for every kind o regional protection available): ARIPO (BW, GH, f English (26) Publication Language: GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, (30) Priority Data: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, PA 2010 00807 9 September 2010 (09.09.2010) DK EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (71) Applicant (for all designated States except US) : TRIFOLMC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, LIUM APS [DK/DK]; Kongevejen 153, DK-2830 Virum TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (DK). ML, MR, NE, SN, TD, TG). (25) Filing Language: English (72) Inventors; and (75) Inventors/ Applicants (for US only): HESLET, Lars [DK/DK]; Parkovsvej 20, DK-2820 Gentofte (DK). FIALA, Kaare [DK/DK]; Egernvej 69, DK-2000 Frederiksberg (DK). (74) Agent: H0IBERG A/S; St. Kongensgade 59 A , DK-1264 Copenhagen K (DK). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, Published: — — with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt o f amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) — (88) Date of publication of the international search report: 16 August 2012 < o © o (54) Title: AIRWAY ADMINISTRATION O F ANGIOGENESIS INHIBITORS (57) Abstract: The present invention provides methods for the local pulmonary treatment of lung metastases and/or primary lung cancer, such a s squamous lung cancer and/or small cell lung cancer, using local deposition of one or more agents capable of inhib it ing angiogenesis and/or an agent that acts a s an active anti-cancer agent and/or an active anti-metastatic agent. The agent capable of inhibiting angiogenesis and/or which acts a s an active anti-cancer agent and/or an active anti-metastatic agent i s administered to a patient with cancer a s a treatment of said metastasis and/or cancer or t o extend the lifespan for said cancer patient with reduced sys temic side- effects compared t o other treatment forms. The agent capable of inhibiting angiogenesis and/or which acts a s an active anti-cancer agent and/or an active anti- metastatic agent i s administered intratracheal, intrabronchial, intraalveolar or broncioalveol ar. Administration for example via inhalation of an aerosol or a s a dry powder and/or administered a s a bronchoalveolar lavage (BAL) an effective amount of the agent. o A . CLASSIFICATION O F SUBJECT MATTER INV. ADD. A61K9/72 A61K31/454 A61P35/00 A61P11/00 A61K9/00 According t o International B . FIELDS SEARCHED Minimum documentation Patent Classification (IPC) o r t o both national classification and IPC searched (classification system followed b y classification symbols) A61K A61P Documentation searched other than minimum documentation t o the extent that such documents are included in the fields searched Electronic data base consulted during the international search (name o f data base and, where practicable, search terms used) EPO-Internal , BIOSIS, EMBASE, WPI Data C . DOCUMENTS Category* CONSIDERED T O B E RELEVANT where appropriate, o f the relevant passages Relevant t o claim No. Citation o f document, with indication, WO 2005/046593 A2 (CELGENE CORP [US] ; ZELDIS JEROME B [US] ) 2 6 May 2005 (2005-05-26) pages 1 , 3 , 10 2009/108932 A2 (UNIV JOHNS HOPKINS) 3 September 2009 (2009-09-03) pages 3 , 5 ,51 ; c l aims 2009/080830 Al (BI0TEST AG 1-11 , 18-29 W0 1-8, 14, 15 , 18-29 W0 [DE] ; IMMUN0GEN INC [US] ; KRAUS ELMAR [DE] ; BRUECHER CHRIST) 2 July 2009 (2009-07-02) 1-8, 14, 15 , 18-29 pages 5 ,28,38; W0 c l aims 1-8, 12 , 13 , 18-29 03/014315 A2 (CHI LDRENS MEDICAL CENTER [US] ; ENTREMED INC [US] ) 2 0 February 2003 (2003-02-20) pages 1 ,28 -/-X| Further documents are listed i n the continuation : "T" later document published after the international filing date o r priority date and not i n conflict with the application but cited t o understand the principle o r theory underlying the invention "X" document o f particular relevance; the claimed invention cannot b e considered novel o r cannot b e considered t o involve a n inventive step when the document is taken alone "Y" document o f particular relevance; the claimed invention cannot b e considered t o involve a n inventive step when the document is combined with one o r more other such documents, such combination being obvious t o a person skilled i n the art "&" document search member o f the same patent family search report o f Box C . XI See patent family annex. * Special categories o f cited documents "A" document defining the general state o f the art which is not considered t o b e o f particular relevance "E" earlier application filing date o r patent but published o n o r after the international "L" documentwhich may throw doubts o n priority claim(s) orwhich is cited t o establish the publication date o f another citation o r other special reason (as specified) "O" document means referring t o a n oral disclosure, use, exhibition o r other filing date but later than "P" document published prior t o the international the priority date claimed Date o f the actual completion o f the international Date o f mailing o f the international 19 June 2012 Name and mailing address o f the ISA/ European Patent Office, P.B. 5818 Patentlaan 2 N L - 2280 H V Rijswijk Tel. (+31-70) 340-2040, Fax: (+31-70) 340-3016 03/07/2012 Authorized officer Hel l er, Dorothee C(Continuation). Category* DOCUMENTS CONSIDERED TO B E RELEVANT Relevant to claim No. Citation of document, with indication, where appropriate, of the relevant passages WO 2007/127488 A l (SHENOY NARMADA R [US] ) 8 November 2007 (2007-11-08) pages 1 ,42 ,52 ; exampl e V CARMELI ET P ET AL: "ANGI0GENESIS I N CANCER AND OTHER DISEASES" , NATURE: INTERNATIONAL WEEKLY JOURNAL O F SCI ENCE, NATURE PUBLISHING GROUP, UNITED KINGDOM, 1-29 1-29 vol . 407 , no. 6801 , 14 September 2000 (2000-09-14) , pages 249-257 , XP000918984, ISSN : 0028-0836, D0I : 10. 1038/35025220 abstract; tabl e s SANDLER ALAN ET AL: 1-29 " Pacl i taxel -carbopl ati n a l one o r wi t h bevaci zumab for non-smal 1 -eel 1 l ung cancer" , NEW ENGLAND JOURNAL O F MEDICINE, THE, MASSACHUSETTS MEDICAL SOCI ETY, WALTHAM, MA, US, vol . 355 , no. 24, 14 December 2006 (2006-12-14) , pages 2542-2550, XP002593420, ISSN : 0028-4793 abstract Patent document cited in search report Publication date Patent family member(s) Publication date W O 2005046593 A2 26-05-2005 AU BR CA CN EA EP EP P KR OA US WO ZA US WO 2004288714 PI0416275 2545128 1901911 200600921 1684758 2077112 2007510670 20060124607 13284 2007208057 2005046593 200603718 Al A Al A Al A2 Al A A A Al A2 A 26-05-2005 23-01-2007 26-05-2005 24-01-2007 27-10-2006 02-08-2006 08-07-2009 26-04-2007 05-12-2006 31-01-2007 06-09-2007 26-05-2005 26-09-2007 06-01-2011 03-09-2009 03-03-2010 02-07-2009 02-07-2009 02-02-2011 27-10-2010 10-03-2011 03-09-2010 01-08-2009 17-09-2009 02-07-2009 15-05-2009 20-02-2003 15-06-2009 02-06-2004 24-09-2009 30-06-2010 24-12-2004 25-11-2005 21-07-2009 24-07-2003 10-05-2007 20-02-2003 26-04-2006 W O 2009108932 A2 03-09-2009 2011003710 A l 2009108932 A 2 069980 2008339911 2710471 101965366 2242772 2011507932 20100097753 200932272 2009232810 2009080830 428419 2457319 1423115 1423115 2325916 4494013 2004538322 531294 1423115 2003139451 2007105903 03014315 200400924 Al Al Al W 0 2009080830 Al 02-07-2009 AR AU CA CN EP P KR TW US WO A Al A A A Al Al W 0 03014315 A2 20-02-2003 AT CA DK EP ES T Al T3 A2 T3 B2 P JP NZ PT US US WO ZA A A E Al Al A2 A Al W 0 2007127488 Al 08-11-2007 EP JP US WO 2019649 2010500050 2010021519 2007127488 A Al Al 04-02-2009 07-01-2010 28-01-2010 08-11-2007