Synthesis Of Desacetoxytubulysin H And Analogs Thereof

  • Published: Sep 4, 2008
  • Earliest Priority: Feb 27 2007
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Compounds of formula I, XVI and XXI possess potent cell growth inhibitory activity. These compounds are described have therapeutic utility, particularly in the treatment of cancer as well as conditions and disorders related to uncontrolled cell growth wherein the variables R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, X, Y and Z are described herein.


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