Methods And Compositions For Identifying Undifferentiated Stem Cells And Assessing Cell Health

  • Published: Dec 27, 2016
  • Earliest Priority: Jan 10 2008
  • Family: 4
  • Cited Works: 16
  • Cited by: 0
  • Cites: 3
  • Additional Info: Cited Works Full text
Abstract

Disclosed herein are methods and compositions for the identification of teloRNA marks to assess the differentiation status of an individual stem cell or a population of stem cells, to diagnose whether and to what extent a stem cell or stem cell culture has already initiated cell differentiation, and to monitor the differentiation status of an individual stem cell or a stem cell culture during passage. The use of these methods and compositions to monitor the pluripotency and differentiation status of a stem cell or stem cell culture during differentiation enables the identification of undifferentiated and pluripotent stem cells prior to the initiation of differentiation. The methods and compositions can also be used to assess and maintain cell viability; to identify cells or a population of cells that are in a state of poor cell health; and to reduce cell growth or treat a diseased cell including, for example, pre-cancerous cells, cancerous cells, apoptotic cells, aging cells, cells undergoing stress, and otherwise diseased or dysfunctional cells.


Claims
Download PDF
Document Preview
Document History
  • Publication: Dec 27, 2016
  • Application: Jan 12, 2009
    US US 81248909 A
  • Priority: Jan 12, 2009
    US US 81248909 A
  • Priority: Jan 12, 2009
    US US 2009/0000180 W
  • Priority: Jan 10, 2008
    US US 1061508 P

Download Citation


Sign in to the Lens

Feedback