Chloride Transporter Clc-7 And Cell-based Screening Method

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Abstract

The invention relates to a CIC-7 protein that is presented on the cell surface and/or plasma membrane, characterised in that the interaction between CIC-7 and the endosomal and/or lysosomal sorting machinery, such as one or more adaptor proteins (AP) and/or Golgi-localized, ³-ear containing, Arf-binding adaptor proteins (GGA), is inhibited and/or disrupted, preferably by mutation or deletion of the amino acid sequences of one or more AP and/or GGA recognition motifs. The invention further relates to a cell-based assay system in which a CIC-7 protein is presented on the cell surface and/or plasma membrane of a cell, with which test compounds are screened for activity in modulating proton and/or chloride transport via CIC-7. Such compounds are intended for application in the treatment of osteoporosis.


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Document History
  • Publication: Feb 22, 2012
  • Application: Aug 16, 2011
    EP EP 11177708 A
  • Priority: Aug 16, 2011
    EP EP 11177708 A
  • Priority: Aug 16, 2010
    EP EP 10075351 A

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